Technical Grade, Oral Grade, Injection Grade Hydroxypropyl Beta Cyclodextrin Hpbcd/Hpcd CAS 128446

Basic Info.

Model NO.	py0037
Transport Package	Drum
Specification	25kg/drum
Trademark	puya
Origin	China
HS Code	3001200020
Production Capacity	5000kg/Month

Product Description

Technical grade, oral grade, injection grade Hydroxypropyl Beta Cyclodextrin Hpbcd/Hpcd CAS 128446-35-5

Hydroxypropyl-β-cyclodextrin is less toxic than the parent cyclodextrin, is non-toxic orally, and has low hemolytic properties.

Proven for oral and injection through a large number of animal experiments and clinical trials

Hydroxypropyl beta-cyclodextrin are purified polydisperse products resulting from the controlled reaction of oxide and native beta-cyclodextrin.

Hydroxypropyl beta-cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound.

Product Name	Hydroxypropyl-beta-cyclodextrin
CAS No.	128446-35-5
Appearance	White Powder
Purity	98.0% --101.0%
MF	C105H196O56
Molecular weight	2354.64614
Quality standard	USP43-NF38
Standard	CP, USP, EP
Other Grade	Oral Medicine grade, technical grade, Injection grade

Inspection items	CP2015	USP43-NF38
character	This product is white or nearly white amorphous or crystalline powder; odorless, slightly sweet; strong moisture absorption. Verysoluble in water, soluble in ethanol.	This product is white or nearly white amorphous or crystalline powder; soluble in water .
Molar substitution degree	N/A	0.4-1.5
PH value	PH5.0-7.5	N/A
Clarity and color of solution	It should be clear and colorless	1.0g/2ml aqueous solution is clear and transparent
Water content	≤6.0%	≤10.0%
Chloride	≤0.05%	N/A
Beta cyclodextrin	≤0.5%	≤1.5%
1.2-propanediol	≤0.5%	≤2.5%
Residue on ignition	N/A	≤1.0%
Heavy metal	≤0.001%	N/A
Hydroxypropyloxy content	19.6%~26.3%	N/A
Total aerobic bacteria (CFU / g)	N/A	≤1000cfu/g
Total number of mould and yeast (CFU / g)	N/A	≤100 cfu/g
Bacterial endotoxin (EU / g)	N/A	According to the needs of the preparation

Function
Hydroxypropyl beta-cyclodextrin are purified polydisperse products resulting from the controlled reaction of pro oxide and native beta-cyclodextrin. Hydroxypropyl beta-cyclodextrin is itself very soluble in water (greater than 500 mg/ml at room temperature compared to 18 mg/ml for beta-cyclodextrin), and is used for molecular encapsulation of a variety of sparingly water compounds to enhance the aqueous solubility of the encapsulated compound.
Application
In PharmaceuticalsHydroxypropyl beta cyclodextrin is a solution to insoluble or low solubility drugs(including plant extracts).Through molecular encapsulation,it could increase the drug solubility and control the release rate of the drug,increase the drug's bioavailability and reduce the toxic side-effets.1. Suitable for parenteral use, syrups, solutions and oral suspensions as well as for dry formulations (with possibility of in-situ encapsulation).2. To increase water solubility of poorly soluble drugs.3. To increase bioavailability.4. To improve organoleptic properties of bitter or unpleasant actives.In CosmeticsHydroxypropyl beta cyclodextrin used as stabilizer,emulsifier and odor absorber.It could reduce organic molecules stimulation to skin mucosal and enhance the stability of the effective components.Prevent volatile ,oxidation of nutrient composition ,increase the solubility of insoluble flavours and fragrances and keep the fragrance slow releasing and lasting.1. Suitable for encapsulation of volatile compounds.2. To increase shelf life of expensive flavours